OUR PRODUCT

Allterum’s Antibody

Allterum is developing 4A10, a monoclonal antibody targeted against IL-7Rα. IL-7Rα is part of a receptor complex located on T-cell and B-cell leukemia cells. Especially in the context of T-cell leukemia cells, IL-7Rα plays a critical role in driving cancer growth. IL-7Rα is frequently expressed at a higher level, or is more active, in T-cell leukemia cells, and has been posited as playing a key role in ALL oncogenesis and chemotherapy-resistance. Allterum’s 4A10 antibody is the first immunotherapy approach to target IL-7Rα in leukemia. 4A10 uses the patient’s own immune system to target leukemia cells for destruction. 4A10 is currently in development for the treatment of relapsed pediatric leukemia.
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4A10 and IL-7Rα in Scientific Literature

IL-7R is highlighted for its potential oncogenic effects in T-cell ALL

IL-7R signaling can drive leukemia development, acceleration, and resistance to chemotherapy

Targeting IL-7R with an antibody-drug conjugate is efficacious in models of T-cell ALL

IL-7R may play a key role in driving Ph-like and Ph+ B-cell acute lymphoblastic leukemia

IL-7Rα is a promising target for the treatment of pediatric acute lymphoblastic leukemia

ALLTERUM THERAPEUTICS

Advancing an innovative solution for a critical and unmet medical need